Lymphoma

Have you noticed cytarabine syndrome outside of 7+3 induction? and when you consider it, are there specific labs you could order? I have a lymphoma patient getting BEAM, he started 100 mg/m2 cytarabine BID on recently and started having soon after.

Breast Cancer | Age 66

66y/o female with metastatic recurrent ER 50%, PR 25% Ki-67 40%, Her 2 neg (2+/FISH neg) patient with Brachial plexus involvement resulting in Loss of function of Right arm and significant bone metastasis. Her XRT is planned for next the 6 weeks. Is it safe to start Ribociclib while patient is on XRT or should we wait for XRT to complete and then start CDK 4/6?

GI Cancer | Age 78 | New Dx

I would like to learn your approach if you had a 78YM ECOG 1 with pT3N0M0 transverse colon adenocarcinoma s/p R hemicolectomy and not a CEA secretor and the only risk feature identified on path being moderately to poorly differentiated adeno. Would you offer adjuvant chemo? Would you obtain ctDNA?

Hematology

Would you treat this case of PNH as PNH with hemolysis or PNH with bone marrow failure? I was thinking of giving a trial of Eculizumab/Ravulizumab in PNH with BMF while waiting for transplant, however, it is not expected to work.

AML | Age 49 | New Dx

My pt was diagnosed with intermediate risk AML (FLT3-ITD) she finished Induction with 7+3+Midaustaurin then 4 cycles HiDAC+Midaustaurin, pt won't get transplant (due to social situation). For maintenance should I do HMA (Po azacitidine)? Or quizartinib? Can I do quizartinib even if she didn't receive it during induction or maintenance (we used midaustaurin). NCCN specifically says quizartinib.

GU Cancer | Age 62

62 y/o M with pT3a, N0, M0, adenocarcinoma of the prostate, Gleason score 5+4 equals 9, and a pretreatment PSA level of 7.56, status post radical prostatectomy in 2022, had +EPE at the time, now having rising PSA up to 0.38. PSMA PET showed a left obturator lymph node. He is starting Lupron, do you typically add on abiraterone for these patients? If so, for what duration?