Breast Cancer | Age 55 | R/R

55yo female with heavily pretreated, metastatic HER2+ breast cancer. She has been re-biopsied three times along the way, always showing ER0PR0HER2 3+ (most recently in the lungs when she progressed on TDXd). (1) what treatment would you recommend upon progression? (2) what role does further genetic testing play here ie: foundation?

cHL | Age 30 | R/R

30M diagnosed with classic HL in 2016. Treated through multiple different therapies. Recently, he had scans that showed FDG avid adenopathy in his neck and biopsy has confirmed lymphoma. The BMT team says they’d be willing to do DLI if I get him back into at least a PR. Would BV-benda be reasonable?

Multiple Myeloma | Age 47 | New Dx

47 year old female referred for monoclonal gammopathy evaluation. Skeletal survey reported "isolated small lucent lesion in temporal calvarium measuring 5 mm". Workup showing smoldering myeloma. Except for those "calvarium spots." which I favor are benign. I'm considering MRI brain vs. PET/CT. Wanted to ask if you have had any suggestions/recommendations.

GU Cancer | Age 70 | New Dx

70 yo male presented with de novo metastatic urothelial carcinoma to lymph nodes and liver, treated front line with cisplatin/gemcitabine with significant partial response, now he has been on maintenance avelumab for a year. How long do you continue maintenance avelumab for?

GI Cancer | Age 78

78y male with cecal mass on c-scope, EGD clear. He had right hemicolectomy that showed 7cm invasive adeno, mod diff in Cecum. However 1/28 nodes and 2 peritoneal nodules show poorly diff signet ring adeno, possible second primary. His CT CAP is negative. Would you do anything further to search for a second primary? Also in this age group I typically used FOLFOX/Bev with low threshold for dose reductions because my worry about the 130mg/m2 oxali dose in CapeOx. What is your experience with CapeOx?

Classical Hematology | Age 46 | New Dx

46-year-old male presents for a new diagnosis of a superficial vein thrombosis. He took a plane flight to China as part of a business trip. When he returned to the United States, he developed swelling of his right leg. An ultrasound of the leg is performed that reveals an SVT that measures 7 cm in size and it is located 2 cm away from the saphenofemoral junction. He is very concerned about developing a DVT given that he travels a lot for his work. In addition to supportive care what should be recommended?