Hodgkin Lymphoma | Age 31 | R/R

Patient has a heavily treated history of nodular sclerosing HL refractory to several lines of treatment. His current regimen on pembrolizumab has been discontinued due to manifesting with severe recurrent pancreatitis and arthralgias believed to be immunotherapy toxicity-related. Are there any other options to treat in this patient, acknowledging he wants continued aggressive treatment given his age?

GI Cancer | Age 86 | New Dx

86 yr male with pT3N1b moderately diff sigmoid colon adenoca. PS 0. MLH1 and PMS2 deficient. Should that result impact his therapy or since his tumor is dMMR offer xeloda +/- oxaliplatin? Have you used half dose oxali per FOCUS2 data?

Classical Hematology

27yr old referred to me for menorrhagia from Gyn after FVIII activity came back at 39%. VWF panel normal. Bleeding score 1. I'm having trouble getting Hemophilia genetic testing done. She would also like to know for future conception purposes. In the interim would you recommend tranexamic acid for her?

CLL | Age 63 | New Dx

63 y/o female with HTN, HLD and good PS presenting with adenopathy and B symptoms with thrombocytopenia and anemia. Diagnosed with poor risk CLL with 17p del. How do you choose frontline therapy? Is zanubrutinib a good option?

Lung Cancer | New Dx

New presentation of a 65 year old female with FDG PET avid lung nodules in contralateral lobes. Indeterminate lymph nodes on imaging. In planning for optimal workup, how do you approach these patients in biopsy and NGS testing in order to determine whether these are synchronous lesions vs metastatic picture?

Non-Hodgkin Lymphoma | Age 62 | R/R

For marginal zone lymphoma with significant bone marrow involvement resulting in cytopenias and PRBC-transfusion dependence, do you have a preferred regimen to maximize bone marrow response?