Breast Cancer | Age 35

35 year old post lumpectomy with 1cm TN, gr 3, N0 disease. I proceeded with TC x 4 but am always torn with these tumors 1-2cm. Generally I opt for TC less than 1 and AC-T over 1cm for TN. After reviewing Plan B and success C, now I’m wondering if for these 1-2cm, should I be pushing more for TC x 6 so as to not have any inferior DFS?

MDS | Age 88 | New Dx

88 yo male with MDS. Excess blasts - 1 - IPSS-M score Moderate High. IPSS-R score: Intermediate. - Bone marrow 2022 with 5-9% blasts, 40-50% cellularity, normal cytogenetics. We discussed chemo vs EPO and opted for EPO. Hg minimally responsive to increasing doses of EPO. Would you add Revlimid or consider HMA next?

GI Cancer | Age 54 | R/R

54-year-old woman diagnosed with stage IIIA colon cancer, s/p sigmoidectomy and adjuvant FOLFOX x6 months. She has been on surveillance with no evidence of disease recurrence until recently when she was found to have a 1 cm nodule in the lung. It was surgically resected and showed metastatic CRC. She is young but has many other medical issues. There is no other evidence of metastatic disease. What should be done next?

Non-Hodgkin Lymphoma | Age 75 | New Dx

I am treating a double hit DLBCL. He has completed 6 cycles of da-repoch. His pet scan showed deauville score 2. What would you do next?

Lung Cancer | Age 69 | New Dx

Would you offer Osmertinib for resected Adeno EGFR exon 19 (AJCC 8TH EDITION): pT2a pN0 based on pleural invasion with size of 1.8 cm after Chemotherapy with neg ctDNA after surgery?

MDS/MPN | Age 65

65M w/ MDS/MPN-unspecified (5-10% blasts on marrow, normal karyotype but 7 tier 1 molecular lesions). Not a transplant candidate. He has a very proliferative phenotype. Symptoms have improved with hydrea and then 2 rounds of decitabine but he has become transfusion dependent (1-2 pRBCs/week), WBC remains >80k, and repeat marrow is unchanged with >95% cellularity and 8% blasts. Do you think Ven/Aza is appropriate?