56 year old gentleman with metastatic BRAF V600E mutant colorectal cancer who received frontline mFOLFOX+avastin with 5FU/avastin maintenance. Progressive disease so placed on therapy with cetuximab+braftovi. Based on the trial, it seems this therapy requires ongoing weekly cetuximab infusions until progression. Is there an alternative infusion schedule or approach that is logistically easier on the patient? Or will he need weekly infusions until progression?
I always dose cetuximab as 500mg/m2 IV q14 days (rather than the weekly schedule). if you need a reference, you could use this one: PMID 36705061. We have more observational data for this dosing schedule, but anecdotally they are the same.
